https://kambayashilab.com/contact daily 0.75 2021-08-13 https://kambayashilab.com/home daily 1.0 2024-04-06 https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1628889342035-OV3RIUIC62TBL1N2JR9V/Sebum+image.png Home https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1629050787589-70SFRGWDR3JW7YMS2J5G/%E3%82%B9%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%B3%E3%82%B7%E3%83%A7%E3%83%83%E3%83%88+2021-08-14+%E5%8D%88%E5%89%8D7.56.02.png Home https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1629062258284-EOFXUYVHG9W5TZ8ADSZV/Screen+Shot+2021-08-15+at+5.17.05+PM.png Home https://kambayashilab.com/lab-members daily 0.75 2024-04-07 https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/f3439d2e-4e48-45f3-9035-d2a660cb2e80/Taku.jpg Lab Members - Dr. Taku Kambayashi, MD/PhD Principal Investigator, Associate Professor of Pathology and Laboratory Medicine Growing up, I have always wanted to work in the field of medicine and to take care of people with disease. After being mesmerized by research experiences during my training, I dreamed of helping patients not only through direct care but also through my research. Now, I am doing exactly that; I am a physician scientist and wear two hats: one as a medical doctor and another as a scientist. I believe that my role as a physician scientist is to bridge basic science and clinical medicine. In essence, physician scientists help to transition “bench to bedside”. Accordingly, a life-long goal of mine has been to help patients through the translation of basic science discovery into therapeutics or diagnostics in a clinically meaningful manner. As such, the research interests of my lab have been focused on intracellular signaling pathways that could be therapeutically targeted to alter the function and development of immune cells, which could potentially provide benefit to disease outcome. Most importantly, I believe it is important to have fun and to be excited at what we do. We try out a lot of things in the lab, always keeping an open mind and allowing the data to lead the path. Sure, we all work hard in the Kambayashi lab, but I strive to promote a lab environment that is collaborative, stimulating, and fun for everyone. https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1630610952632-1Y7AQNLO1OILJYKMFA2C/IMG_5113.JPG Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1630610977509-XK67MH7KUU4O72XE8QZF/516042A4-A899-4A7E-9BEC-6130FF4BC852.JPG Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/9b3f6f54-550d-4afa-8d71-8f681c6c1cfe/Simon+Zhou+Mugshot.png Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/0ee87bc0-6c11-460a-8b29-fa0e8aca70e4/Jordan+Harris+Mugshot.png Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/b3e30610-6587-4c8b-a3e2-672e20320627/Wei+.png Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/f2c1697c-3e5f-4850-ac4f-f0172353ea05/Lily+Mugshot.jpg Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/8ba1f04b-a77e-4ee1-ba03-99bf51e58295/Bruk+mugshot.jpg Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/86c43f26-ec2c-4662-874f-1789896d107f/Dorottya+Laczko%2C+MD+mugshot.jpg Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/2126d9ca-babf-451a-986b-f64948f96abc/Esha+mugshot.jpg Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1dfd335b-d31e-49f7-8af6-1a2988222742/MinJu+mugshot.png Lab Members https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/68160eb6-087f-43a1-8973-b8d4cd5e5a97/Tetsuya+Ikawa+MD+PhD+mugshot.jpg Lab Members https://kambayashilab.com/projects daily 0.75 2024-04-07 https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/c8db145b-5968-45fe-9bfe-354be8240cc2/Jordan+graphical+abstract.png https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/cdf61b54-68eb-4a8f-8cee-e0060d9d60eb/Jordan+project+model.jpg https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1629062353339-PQT5E44ZTY5UQNYXCF3H/Screen+Shot+2021-08-15+at+5.17.05+PM.png Projects - DGK as a novel checkpoint target for reactivation of exhausted T cells Diacylglycerol (DAG) is an important second messenger downstream of T cell activation through their T cell receptor (TCR). DAG is negatively regulated by a kinase called DAG kinase (DGK), which phosphorylates DAG into phosphatidic acid, thereby terminating DAG-mediated signaling. Our previous work has shown that DGK deficiency leads to heightened NK cell and T cell activation and resistance to PD-1-mediated inhibition. Ongoing projects in the lab involve the investigation of how DGK and its downstream pathways (such as ERK) affect T cell responses during chronic viral infection with LCMV clone 13. https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1629062397670-IC79IASQTBK2TIE14JOL/%E3%82%B9%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%B3%E3%82%B7%E3%83%A7%E3%83%83%E3%83%88+2021-08-14+%E5%8D%88%E5%89%8D7.56.02.png Projects - Developing a mouse model of Idiopathic Multicentric Castleman Disease (iMCD) iMCD is a rare but life-threatening cytokine storm disorder of unknown etiology. To understand more about iMCD pathogenesis, we have been studying the signaling pathways and transcriptomics in cells from iMCD patients. Through this work, we have identified a number of key signaling molecules that might be important in iMCD pathogenesis including mTOR and IFN signaling. We are currently developing mouse models of iMCD to mechanistically test the role of these pathways in this devastating disease. https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1628890438979-ZRI82J3ECRV9Z30E8YSH/Sebum+image.png Projects - Immune-mediated control of sebum secretion by the skin We have recently discovered that T cells that are stimulated by a keratinocyte-derived cytokine TSLP induces sebum secretion from sebaceous glands of the skin. Sebum is a high calorie lipid-rich substance that provides barrier protection to the skin. When this sebum secretion system is put into high gear, we found that high fat diet-fed mice selectively lose adipose tissue and lower their tissue triglyceride levels, providing benefit to obesity-related disorders. At homeostasis, we believe that the T cell/TSLP/sebum axis is important for providing skin barrier function in response to pathogens and commensals. Ongoing projects involve the investigation of the mechanism by which TSLP-stimulated T cells promote sebum secretion and how this axis interacts with skin commensals and pathogens. https://kambayashilab.com/publications daily 0.75 2024-04-03 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg Publications https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Publications https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Publications https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847743861-GWVMBPD7Z7WQRQL9IZZ8/Large+JPG-Aro+Ha_0380.jpg Publications https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607628784608-5D22G9GPLHDSAB2IXC2G/Large+JPG-Aro+Ha_0638.jpg Publications https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607638148090-Y6OFDI575CM3NQV732RJ/Large+JPG-Aro+Ha_0387.jpg Publications https://kambayashilab.com/photos daily 0.75 2024-03-21 https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/c8c89647-2132-4435-91da-c594bbc5b245/Mariko+Bday+2024_2.png Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1600a284-78e4-4c65-ba7d-ac8439ff3cea/Mariko+Bday+2024_3.png Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/8f5d3b0a-6d92-4974-93f8-b7e153ec11d4/Mariko+Bday+2024_1.png Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1711060308928-IJLA7XV7LQGLQPY28ICH/tempImageYkcykm.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/290e36ef-36c0-4683-91da-82a1bd6b9521/Kambayashi+lab+at+Buna+7+the+best.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/be973f16-f89e-4e45-8e2b-8a9b18f63431/Holiday+pic+from+Taku+house.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/6a41f225-e42b-4321-99ad-e320bf449f47/Yuichi%27s+superman+photo.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/9d571e13-52ca-45d8-a5f1-caf8a4474cc6/Shohei%27s+goodbye+pic.JPG Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/1711060259218-C0KP2VMC9BC39A7O4QCK/tempImageFMc0uC.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/fb4b9836-9f6c-4880-9bb9-eaa0b1022307/Ruth+paper+w+Taku+on+Philly+Inquirer.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/42e2c6bd-03b5-4179-9dd6-c0895e25358b/Jordan+Yuichi+having+fun+in+Japan.jpg Photos https://images.squarespace-cdn.com/content/v1/603eae4d2666392117c4caca/4f3ab7b6-f09f-41cc-aba8-c29851762a9c/Taku+Jord+Yuichi+Japan+1.jpg Photos